Retro-1-Oligonucleotide Conjugates. Synthesis and Biological Evaluation
Addition of small molecule Retro-1 has been described to enhance antisense and splice switching oligonucleotides.With the Hockey Protective - Shin Pads - Senior aim of assessing the effect of covalently linking Retro-1 to the biologically active oligonucleotide, three different derivatives of Retro-1 were prepared that incorporated a phosphoramidit